Here's an excerpt from Entertainment Weekly:
(Lindelof suggests studying Desmond's mural for clues...or waiting patiently for him to share what he knows on Oct.5).
Still, he's banking that fans will dig the guessing games.
"I don't think the audience wants us to take away their ability to play along," Lindelof says.
"Then again, they may not realize how much they like it until we take it away."

Here's a list of what we see:

1. fish (more than 1)
   
2. A sun
   
3. A flower of some kind ?
   
4. The numbers 8, 16, 42, 108 (which is the sum of all the cursed numbers)
   I'm sure the rest of them 4 and 23 are in there somewhere
   
5. 2 small white houses
   
6. a strange blue sea creature looking thing - or it could be the waves that overtook the wreckage?
   
7. 2 faces
   
8. I count 14 stick figures so far and one is inside a red stain - blood? (could be Boone or anyone who's died so far)
   
9. It looks like someone was counting the days - hash marks
   
10. a large white arrow pointing north?
    
11. an eye
    
12. The words "M SICK" You could use the "eye" for I'm sick or there does seem to be something just in front of the letter M
    
13. Above the word SICK are 2 stick men, one upside down.

Compare this to the painting in Thomas and Claires' apartment. It's eerily similar picture of Thomas painting